Members of the Protein Tyrosine Phosphatase (PTPs) family are associated with growth regulation and cancer development.Acting as natural counterpart of tyrosine kinases (TKs), mainly involved in crucial signaling pathways such as regulation of cell cycle, proliferation, invasion and angiogenesis, they represent key parts of complex physiological ho

Carla de Sanctis Pecora Dermatologie-Clínica, Cirurgia, Cosmiatria e Laser, São Paulo, BrazilCorrespondence: Carla de Sanctis Pecora Avenida Ibirapuera, 2907, Conj.901, Moema, São Paulo, SP CEP: 04029-200, BrazilTel/Fax +55 11 50420871Email [email protected]: It is well known that incobotulinumtoxinA (INCO) is a

The identification of protein kinase targets remains a significant bottleneck for our understanding of signal transduction in normal and diseased cellular states.Kinases recognize their substrates in part through sequence motifs on substrate proteins, which, to date, have most effectively been elucidated using combinatorial peptide library approach

IntroductionAnal canal duplication (ACD) is a rare entity of gastrointestinal duplication that may be asymptomatic or present complications, such as abscess, fistulae, or malignant changes.The diagnosis and rational management of ACD still need to be clarified.Case presentationWe present a case of an 18-month-old girl with intractable perianal eros

Multiple Launch Rocket System (MLRS) Welding Positioner has been widely used in recent years; vibration control in launching process is an effective way to improve its dispersion characteristics.In this paper, a novel vibration control system applying Annularly Arranged Thrusters (AAT) for MLRS in launching process is introduced and the prototype o